31 January 2022
10.00 – 12.30 UK/
13.00 – 15.30 Moscow

Neurodegenerative Diseases and Brain Plasticity: New Ideas and Avenues of Research


Neurodegenerative diseasessuch as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, belong to most devastating pathologies of the nervous system. Because many of them are age-dependentincrease in human life expectancy leads to their growing spread.According to World Health Organization by 2040 they will become the second commonest cause of death in developed world.They are also a source of great suffering for patients and their families as well as a heavy social and economic burden. Currently dementia alone, caused mainly by Alzheimer's disease, affects over 50 million people around the world. In developed countries, the costs of treatment and care for patients with dementia exceed the costs for the treatment of cancer, cardiovascular diseases and diabetes combined. By 2050, the prevalence of dementia is estimated to double in Europe and triple worldwide.

The global burden of dementia has been recently aggravated by the COVID-19 pandemic. Between March 27, 2020, and Jan 8, 2021, the largest increase in excess mortality in England was observed in people with dementia, among whom mortality was eight times higher than before the pandemic. In March 2021, dementia was the leading cause of death in England.

Despite this importance, there is still a large gap in our knowledge of how the healthy brain transforms into neurodegenerative state. Many data suggest that due to brain plasticity symptoms of dementia may not become noticeable until 15-20 years after a disease like Alzheimer's or Parkinson's starts in the nervous system. Therefore, developing new approaches for early detection of neurodegenerative diseases and mobilizing the capacities of neuroplasticity to postpone the onset of disease is very promising new direction. It will require a shift of scientific focus towards mechanisms underlying the earliest stages of disease, development of new biological and cognitive tests as well as study of plasticity repair/protective mechanismsof the brain and search for new tools of their augmentation.

This online forum will bring together leading UK and Russian experts in the field of neurodegenerative diseases and brain plasticity, who will discuss new ideas and avenues of researchin the topic.
Speakers
John Hardy
Professor, Fellow of the Royal Society, human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at UCL, UK Dementia Research Institute at UCL, read more
Alla Salmina
Professor, Head of the Neurocytology Laboratory, Brain Research Department, "Scientific Center for Neurology"; Chief Researcher, Research Institute of Molecular Medicine and Pathobiochemistry, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, read more
Henrik Zetterberg
Henrik Zetterberg, Professor of Neurochemistry, UK Dementia Research Institute at University College London, UK, and the University of Gothenburg, Sweden, read more
Ilya Bezprozvanny
Professor, Department of Physiology, UT Southwestern Medical Centre at Dallas, Dallas, TX, USA; Laboratory of Molecular Neurodegeneration, Peter the Great St Petersburg State Polytechnical University, St. Petersburg, Russia; Laboratory of Synaptic Biology, Southern Federal University, Rostov-on-Don, read more
Jian Gan
PhD, Group Leader, UK Dementia Research Institute at the University of Edinburgh, Centre for Discovery Brain Sciences, read more
Pavel Balaban
PhD, Professor, Senior Researcher, Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, corresponding member of Russian Academy of Sciences, read more
William Wisden
Professor, UK Dementia Research Institute, Chair in Molecular Neuroscience at Imperial College London, Fellow of the Academy of Medical Sciences, read more
Natalia Gulyaeva
Doctor of Biological Sciences, Professor, Head of the Laboratory of Functional Biochemistry of Nervous System in the Institute of Higher Nervous Activity and Neurophysiology RAS; Head of the Department of Neurobiological Mechanisms of Mental Disorders at Moscow Research and Clinical Center for Neuropsychiatry in Moscow, read more
Marc Aurel Busche
PhD, Programme Leader at the UK Dementia Research Institute at University College London, read more
Sergey Illarioshkin
MD, PhD, Prof., Corresponding Member of the Russian Academy of Sciences, Deputy Director of the Research Center of Neurology, Director of the Brain Institute at the Neurology Research Center, Moscow, read more
Federica Marinaro
PhD, Research Informatics Engagement Manager, Early Detection of Neurodegenerative diseases (EDoN), Alzheimer's Research UK, read more
Alexey Semyanov
PhD DrSc MAE, Senior Researcher and Head of Molecular Neurobiology department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, corresponding member of RAS,
read more
Raffaella Nativio
PhD, UK Dementia Research Institute Group Leader, Imperial College London, read more
Konstantin Anokhin
MD, PhD, Dr.Med.Sci, Member of the Russian Academy of Sciences
Director of the Institute for Advanced Brain Studies, Lomonosov Moscow State University; Head of the Laboratory for Neurobiology of Memory, P.K. Anokhin Research Institute of Normal Physiology,

read more
Vladimir Chekhonin
Academician of the Russian Academy of Sciences, MD, Professor, Vice President of the RAS, Head of the Department of Medical Nanobiotechnologies of the Faculty of Medicine and Biology of the Russian National Research Medical University. N.I. Pirogov, Head of the Department of Fundamental and Applied Neurobiology, N.N.V.P. Serbsky" of the Ministry of Health of Russia, Chairman of the Scientific Council of the Russian Academy of Sciences "Life Sciences", Member of the International Brain Research Organization, Laureate of the Prize of the Government of the Russian Federation in the field of science and technology, read more
Programme
10:00 UK/13:00 Moscow: Welcome to the forum

Moderator: Konstantin Anokhin, Head of Institute for Advanced Brain Studies, Lomonosov Moscow State University
10:10 UK/13:10 Moscow: Keynote

Vladimir Tchekhonin, Vice-President, Russian Academy of Science
10:15 UK/13:15 Moscow: Speakers' Presentations

Speakers Sir John Hardy, Alla B. Salmina, Henrik Zetterberg, Ilya Bezprozvanny, Jian Gan, Pavel Balaban, William Wisden, Natalia V. Gulyaeva, Marc Aurel Busche, Sergey N. Illarioshkin, Federica Marinaro, Alexey Semyanov, Raffaella Nativio, Konstantin Anokhin,Vladimir Chekhonin
Sir John Hardy, Professor, Fellow of the Royal Society, human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at UCL, UK Dementia Research Institute at UCL

Alla B. Salmina, Professor, Chief Researcher & Head, Laboratory of Experimental Brain Cytology, Division of Brain Sciences, Research Centre of Neurology, Moscow, Russia and Chief Researcher, Research Institute of Molecular Medicine & Pathobiochemistry, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Henrik Zetterberg, Professor of Neurochemistry, UK Dementia Research Institute at University College London, UK, and the University of Gothenburg, Sweden

Ilya Bezprozvanny, Professor, Department of Physiology, UT Southwestern Medical Centre at Dallas, Dallas, TX, USA; Laboratory of Molecular Neurodegeneration, Peter the Great St Petersburg State Polytechnical University, St. Petersburg, Russia; Laboratory of Synaptic Biology, Southern Federal University, Rostov-on-Don, Russia

Jian Gan, PhD, Group Leader, UK Dementia Research Institute at the University of Edinburgh, Centre for Discovery Brain Sciences
Title: Real-time interrogation of circuit dynamics in dementia: A single-cell physiology approach

Pavel Balaban, PhD, Professor, Senior Researcher, Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, corresponding member of Russian Academy of Sciences

William Wisden
, Professor, UK Dementia Research Institute, Chair in Molecular Neuroscience at Imperial College London, Fellow of the Academy of Medical Sciences
Title: Does sleep play a role in delaying dementia onset?


Natalia V. Gulyaeva, Doctor of Biological Sciences, Professor, Head of the Laboratory of Functional Biochemistry of Nervous System in the Institute of Higher Nervous Activity and Neurophysiology RAS; Head of the Department of Neurobiological Mechanisms of Mental Disorders at Moscow Research and Clinical Center for Neuropsychiatry in Moscow
Title: Glucocorticoid-dependent mechanisms of brain damage: A vital though underexplored issue

Marc Aurel Busche, PhD, Programme Leader at the UK Dementia Research Institute at University College London

Sergey N. Illarioshkin, MD, PhD, Prof., Corresponding Member of the Russian Academy of Sciences, Deputy Director of the Research Center of Neurology, Director of the Brain Institute at the Neurology Research Center, Moscow

Federica Marinaro, PhD, Research Informatics Engagement Manager, Early Detection of Neurodegenerative diseases (EDoN), Alzheimer's Research UK

Alexey Semyanov, PhD DrSc MAE, Senior Researcher and Head of Molecular Neurobiology department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, corresponding member of RAS

Raffaella Nativio
, PhD, UK Dementia Research Institute Group Leader, Imperial College London
11:40 UK/14:40 Moscow: Discussion

12:20 UK/15:20 Moscow: Moderator to round up the event

12:30 UK/15:30Moscow END
Organisers and Partners
Contacts
university.alliance2021@gmail.com