31 January 2022
10.00 – 12.30 UK/
13.00 – 15.30 Moscow
10.00 – 12.30 UK/
13.00 – 15.30 Moscow
Neurodegenerative Diseases and Brain Plasticity: New Ideas and Avenues of Research
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Neurodegenerative diseasessuch as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, belong to most devastating pathologies of the nervous system. Because many of them are age-dependentincrease in human life expectancy leads to their growing spread.According to World Health Organization by 2040 they will become the second commonest cause of death in developed world.They are also a source of great suffering for patients and their families as well as a heavy social and economic burden. Currently dementia alone, caused mainly by Alzheimer's disease, affects over 50 million people around the world. In developed countries, the costs of treatment and care for patients with dementia exceed the costs for the treatment of cancer, cardiovascular diseases and diabetes combined. By 2050, the prevalence of dementia is estimated to double in Europe and triple worldwide.
The global burden of dementia has been recently aggravated by the COVID-19 pandemic. Between March 27, 2020, and Jan 8, 2021, the largest increase in excess mortality in England was observed in people with dementia, among whom mortality was eight times higher than before the pandemic. In March 2021, dementia was the leading cause of death in England.
Despite this importance, there is still a large gap in our knowledge of how the healthy brain transforms into neurodegenerative state. Many data suggest that due to brain plasticity symptoms of dementia may not become noticeable until 15-20 years after a disease like Alzheimer's or Parkinson's starts in the nervous system. Therefore, developing new approaches for early detection of neurodegenerative diseases and mobilizing the capacities of neuroplasticity to postpone the onset of disease is very promising new direction. It will require a shift of scientific focus towards mechanisms underlying the earliest stages of disease, development of new biological and cognitive tests as well as study of plasticity repair/protective mechanismsof the brain and search for new tools of their augmentation.
This online forum will bring together leading UK and Russian experts in the field of neurodegenerative diseases and brain plasticity, who will discuss new ideas and avenues of researchin the topic.
The global burden of dementia has been recently aggravated by the COVID-19 pandemic. Between March 27, 2020, and Jan 8, 2021, the largest increase in excess mortality in England was observed in people with dementia, among whom mortality was eight times higher than before the pandemic. In March 2021, dementia was the leading cause of death in England.
Despite this importance, there is still a large gap in our knowledge of how the healthy brain transforms into neurodegenerative state. Many data suggest that due to brain plasticity symptoms of dementia may not become noticeable until 15-20 years after a disease like Alzheimer's or Parkinson's starts in the nervous system. Therefore, developing new approaches for early detection of neurodegenerative diseases and mobilizing the capacities of neuroplasticity to postpone the onset of disease is very promising new direction. It will require a shift of scientific focus towards mechanisms underlying the earliest stages of disease, development of new biological and cognitive tests as well as study of plasticity repair/protective mechanismsof the brain and search for new tools of their augmentation.
This online forum will bring together leading UK and Russian experts in the field of neurodegenerative diseases and brain plasticity, who will discuss new ideas and avenues of researchin the topic.
Speakers
John Hardy
Professor, Fellow of the Royal Society, human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at UCL, UK Dementia Research Institute at UCL, read more
Alla Salmina
Professor, Head of the Neurocytology Laboratory, Brain Research Department, "Scientific Center for Neurology"; Chief Researcher, Research Institute of Molecular Medicine and Pathobiochemistry, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, read more
Henrik Zetterberg
Ilya Bezprozvanny
Professor, Department of Physiology, UT Southwestern Medical Centre at Dallas, Dallas, TX, USA; Laboratory of Molecular Neurodegeneration, Peter the Great St Petersburg State Polytechnical University, St. Petersburg, Russia; Laboratory of Synaptic Biology, Southern Federal University, Rostov-on-Don, read more
Jian Gan
PhD, Group Leader, UK Dementia Research Institute at the University of Edinburgh, Centre for Discovery Brain Sciences, read more
Pavel Balaban
PhD, Professor, Senior Researcher, Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, corresponding member of Russian Academy of Sciences, read more
William Wisden
Professor, UK Dementia Research Institute, Chair in Molecular Neuroscience at Imperial College London, Fellow of the Academy of Medical Sciences, read more
Natalia Gulyaeva
Doctor of Biological Sciences, Professor, Head of the Laboratory of Functional Biochemistry of Nervous System in the Institute of Higher Nervous Activity and Neurophysiology RAS; Head of the Department of Neurobiological Mechanisms of Mental Disorders at Moscow Research and Clinical Center for Neuropsychiatry in Moscow, read more
Marc Aurel Busche
Sergey Illarioshkin
MD, PhD, Prof., Corresponding Member of the Russian Academy of Sciences, Deputy Director of the Research Center of Neurology, Director of the Brain Institute at the Neurology Research Center, Moscow, read more
Federica Marinaro
Research Informatics Engagement Manager, Early Detection of Neurodegenerative diseases (EDoN), Alzheimer's Research UK, read more
Alexey Semyanov
PhD DrSc MAE, Senior Researcher and Head of Molecular Neurobiology department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, corresponding member of RAS,
read more
read more
Raffaella Nativio
PhD, UK Dementia Research Institute Group Leader, Imperial College London, read more
Programme
10:00 UK/13:00 Moscow: Welcome to the forum
Moderator: Konstantin Anokhin, Head of Institute for Advanced Brain Studies, Lomonosov Moscow State University
Moderator: Konstantin Anokhin, Head of Institute for Advanced Brain Studies, Lomonosov Moscow State University
10:10 UK/13:10 Moscow: Keynote
Vladimir Tchekhonin, Vice-President, Russian Academy of Science
Vladimir Tchekhonin, Vice-President, Russian Academy of Science
10:15 UK/13:15 Moscow: Speakers' Presentations
Speakers – Sir John Hardy, Alla B. Salmina, Henrik Zetterberg, Ilya Bezprozvanny, Jian Gan, Pavel Balaban, William Wisden, Natalia V. Gulyaeva, Marc Aurel Busche, Sergey N. Illarioshkin, Federica Marinaro, Alexey Semyanov, Raffaella Nativio
Speakers – Sir John Hardy, Alla B. Salmina, Henrik Zetterberg, Ilya Bezprozvanny, Jian Gan, Pavel Balaban, William Wisden, Natalia V. Gulyaeva, Marc Aurel Busche, Sergey N. Illarioshkin, Federica Marinaro, Alexey Semyanov, Raffaella Nativio
Sir John Hardy, Professor, Fellow of the Royal Society, human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at UCL, UK Dementia Research Institute at UCL
Alla B. Salmina, Professor, Chief Researcher & Head, Laboratory of Experimental Brain Cytology, Division of Brain Sciences, Research Centre of Neurology, Moscow, Russia and Chief Researcher, Research Institute of Molecular Medicine & Pathobiochemistry, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Henrik Zetterberg, Professor of Neurochemistry, UK Dementia Research Institute at UCL
Ilya Bezprozvanny, Professor, Department of Physiology, UT Southwestern Medical Centre at Dallas, Dallas, TX, USA; Laboratory of Molecular Neurodegeneration, Peter the Great St Petersburg State Polytechnical University, St. Petersburg, Russia; Laboratory of Synaptic Biology, Southern Federal University, Rostov-on-Don, Russia
Jian Gan, PhD, Group Leader, UK Dementia Research Institute at the University of Edinburgh, Centre for Discovery Brain Sciences
Title: Real-time interrogation of circuit dynamics in dementia: A single-cell physiology approach
Pavel Balaban, PhD, Professor, Senior Researcher, Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, corresponding member of Russian Academy of Sciences
William Wisden, Professor, UK Dementia Research Institute, Chair in Molecular Neuroscience at Imperial College London, Fellow of the Academy of Medical Sciences
Title: Does sleep play a role in delaying dementia onset?
Natalia V. Gulyaeva, Doctor of Biological Sciences, Professor, Head of the Laboratory of Functional Biochemistry of Nervous System in the Institute of Higher Nervous Activity and Neurophysiology RAS; Head of the Department of Neurobiological Mechanisms of Mental Disorders at Moscow Research and Clinical Center for Neuropsychiatry in Moscow
Topic: Glucocorticoid-dependent mechanisms of brain damage: A vital though underexplored issue
Marc Aurel Busche, PhD, Programme Leader at the UK Dementia Research Institute at University College London
Sergey N. Illarioshkin, MD, PhD, Prof., Corresponding Member of the Russian Academy of Sciences, Deputy Director of the Research Center of Neurology, Director of the Brain Institute at the Neurology Research Center, Moscow
Federica Marinaro, Research Informatics Engagement Manager, Early Detection of Neurodegenerative diseases (EDoN), Alzheimer's Research UK
Alexey Semyanov, PhD DrSc MAE, Senior Researcher and Head of Molecular Neurobiology department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, corresponding member of RAS
Raffaella Nativio, PhD, UK Dementia Research Institute Group Leader, Imperial College London
Alla B. Salmina, Professor, Chief Researcher & Head, Laboratory of Experimental Brain Cytology, Division of Brain Sciences, Research Centre of Neurology, Moscow, Russia and Chief Researcher, Research Institute of Molecular Medicine & Pathobiochemistry, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Henrik Zetterberg, Professor of Neurochemistry, UK Dementia Research Institute at UCL
Ilya Bezprozvanny, Professor, Department of Physiology, UT Southwestern Medical Centre at Dallas, Dallas, TX, USA; Laboratory of Molecular Neurodegeneration, Peter the Great St Petersburg State Polytechnical University, St. Petersburg, Russia; Laboratory of Synaptic Biology, Southern Federal University, Rostov-on-Don, Russia
Jian Gan, PhD, Group Leader, UK Dementia Research Institute at the University of Edinburgh, Centre for Discovery Brain Sciences
Title: Real-time interrogation of circuit dynamics in dementia: A single-cell physiology approach
Pavel Balaban, PhD, Professor, Senior Researcher, Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, corresponding member of Russian Academy of Sciences
William Wisden, Professor, UK Dementia Research Institute, Chair in Molecular Neuroscience at Imperial College London, Fellow of the Academy of Medical Sciences
Title: Does sleep play a role in delaying dementia onset?
Natalia V. Gulyaeva, Doctor of Biological Sciences, Professor, Head of the Laboratory of Functional Biochemistry of Nervous System in the Institute of Higher Nervous Activity and Neurophysiology RAS; Head of the Department of Neurobiological Mechanisms of Mental Disorders at Moscow Research and Clinical Center for Neuropsychiatry in Moscow
Topic: Glucocorticoid-dependent mechanisms of brain damage: A vital though underexplored issue
Marc Aurel Busche, PhD, Programme Leader at the UK Dementia Research Institute at University College London
Sergey N. Illarioshkin, MD, PhD, Prof., Corresponding Member of the Russian Academy of Sciences, Deputy Director of the Research Center of Neurology, Director of the Brain Institute at the Neurology Research Center, Moscow
Federica Marinaro, Research Informatics Engagement Manager, Early Detection of Neurodegenerative diseases (EDoN), Alzheimer's Research UK
Alexey Semyanov, PhD DrSc MAE, Senior Researcher and Head of Molecular Neurobiology department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, corresponding member of RAS
Raffaella Nativio, PhD, UK Dementia Research Institute Group Leader, Imperial College London
11:40 UK/14:40 Moscow: Discussion
12:20 UK/15:20 Moscow: Moderator to round up the event
12:30 UK/15:30Moscow END
Organisers and Partners
Contacts
university.alliance2021@gmail.com
university.alliance2021@gmail.com