Natalia V. Gulyaeva is a graduate of Biochemistry Department of Lomonosov Moscow State University, Doctor of Biological Sciences, Professor, head of Laboratory in the Institute of Higher Nervous Activity and Neurophysiology RAS and of Department in Moscow Research and Clinical Center for Neuropsychiatry. An expert in research of molecular and cellular mechanisms of neuroplasticity and brain pathologies.
Her team conducted research on mechanisms of neurodegeneration (including amyloid-dependent) on rodent models and clinical material, described involvement of proteolytic enzymes, free radical processes and NO system in neuronal survival and death, changes of glia and neurogenesis. Mechanisms of selective sensitivity of hippocampal neurons to stressful factors and involvement of neuroinflammation processes in this phenomenon are being investigated. Based on studies on patients with early post-stroke seizures, a hypothesis about NO-dependent mechanisms of their development was formulated. In translational studies of depressive disorders, physiological and molecular/cellular mechanisms of impaired stress-response have been established. A new concept of glucocorticoid-dependent mechanisms of distant damage to the hippocampus as essential link in development of post-stroke and post-traumatic cognitive and depressive disorders, epilepsy and comorbidity of neurological and mental diseases has been formulated and tested in experiments and clinical studies.
Topic: Glucocorticoid-dependent mechanisms of brain damage: A vital though underexplored issue.