Alexey Semyanov
After PhD defence in 1998, Alexey Semyanov joined the lab of Prof. Dimitri Kullmann in the Institute of Neurology at University College London. He discovered that glutamate escaping excitatory synapses can reach presynaptic terminals of inhibitory GABAergic synapses and reduce GABA release probability (Neuron 2000). He found that activation of axonal kainate receptors by glutamate spillover can trigger ectopic action potentials in hippocampal interneurons (Nature Neurosci. 2001). He was first to describe cell-type specificity of tonic GABAA receptor mediated conductance (Nature Neurosci. 2003).
In 2005, Alexey Semyanov joined RIKEN Brain Science Institute as a Unit Leader upon invitation of Prof. Masao Ito. His lab used in vitro and in vivo electrophysiology; two-photon calcium imaging and second-harmonic voltage imaging. Alexey's research was focused on mechanisms and physiological relevance of extrasynaptic signalling and neuron-glia communication. He discovered the dual excitatory and inhibitory effect of extrasynaptic GABAA receptor activation in hippocampal interneurons (Nature Commun 2011), biphasic action of GABAA receptor activation on hippocampal rhythms (PNAS 2014), readout of ambient glutamate concentrations by extrasynaptic NMDA receptors (Cell Reports 2012), retrograde signalling mediated by intracleft K+ accumulation (Cell Reports 2013) etc.
In 2014, Alexey Semyanov moved to the University of Nizhny Novgorod (UNN, Russia) to become the head of Nizhny Novgorod Neuroscience Center upon invitation of Prof. Alexander Sergeev. In October 2016, Alexey Semyanov was elected as a corresponding member of the Russian Academy of Sciences. In September 2017, Prof. Semyanov established a new lab in the Institute of Bioorganic Chemistry (Moscow). Later he became the head of the Molecular Neurobiology department and a deputy director of the institute. Alexey Semyanov was elected as a member of Academia Europaea in 2019. He is also an Honorary Professor at University College London.